Opportunity Information: Apply for RFA NS 19 018
The funding opportunity titled "HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)" (Funding Opportunity Number RFA-NS-19-018) is a National Institutes of Health (NIH) grant competition under the HEAL (Helping to End Addiction Long-term) Initiative. Its central purpose is to support the development and clinical evaluation of device-based approaches intended to treat pain. The mechanism used is a UH3 cooperative agreement, which generally means NIH expects to have substantial scientific and programmatic involvement during the project period rather than serving only as a funder. The notice also states that a clinical trial is optional, indicating applicants may propose either clinical testing or other advanced clinical-stage activities appropriate for a device aimed at pain management, depending on the maturity of the technology and the proposed aims.
This opportunity is categorized as discretionary funding and sits within NIH health-related funding activity areas. The CFDA/assistance listing numbers associated with the announcement include 93.213, 93.273, 93.350, 93.393, 93.846, 93.853, 93.865, and 93.867, reflecting that the program aligns with multiple NIH institutes and program areas that can be involved in pain research and related translational activities. The announcement was created on December 10, 2018, and the original closing date listed is April 15, 2020.
Eligibility is broad and includes many standard domestic applicant types that NIH commonly allows, spanning public sector, academic, nonprofit, and commercial organizations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and tribal organizations other than federally recognized tribal governments. It also includes public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education when applying under the nonprofit categories), for-profit organizations (other than small businesses), small businesses, and other unspecified entities that meet NIH requirements.
The announcement explicitly highlights additional eligible applicant categories, emphasizing inclusion of institutions and organizations that serve specific communities or have particular governance structures. These include Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; Indian/Native American tribal governments that are not federally recognized; and organizations based in a U.S. territory or possession. This framing signals NIH interest in encouraging participation from a wide range of institutional types, including those that may bring specialized community reach, patient populations, clinical settings, or perspectives relevant to pain treatment.
Foreign eligibility is limited in a way that is typical for many NIH device-translation programs. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) components of U.S. organizations are stated as not eligible to apply. At the same time, the announcement allows foreign components as defined in the NIH Grants Policy Statement. In practical terms, that means a U.S.-based applicant organization can include certain international elements of the work (for example, a defined collaboration or performance site) if they meet NIH policy requirements for foreign components, but the primary applicant organization itself must be domestic and the project cannot be structured as a non-U.S. applicant or a non-U.S. organizational component of a U.S. entity serving as the applicant.
No specific award ceiling or expected number of awards is provided in the excerpted data, so applicants would normally need to consult the full FOA text to understand budget expectations, project duration, and any program-specific constraints (such as milestones, go/no-go decision points, device development stage requirements, or expectations around regulatory planning). Overall, the opportunity is aimed at advancing clinical devices that can address pain, under the umbrella of the NIH HEAL Initiative, using a cooperative agreement structure that typically includes active NIH engagement to help guide progress and ensure alignment with program goals.Apply for RFA NS 19 018
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "HEAL Initiative: Clinical Devices to Treat Pain (UH3 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.273, 93.350, 93.393, 93.846, 93.853, 93.865, 93.867.
- This funding opportunity was created on 2018-12-10.
- Applicants must submit their applications by 2020-04-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional) Apply for RFA AT 19 004 Funding Number: RFA AT 19 004 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Tissue Chips to Model Nociception, Addiction, and Overdose (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA TR 19 003 Funding Number: RFA TR 19 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 1630) (UG3/UH3 Clinical Trial Required) Apply for RFA DA 19 035 Funding Number: RFA DA 19 035 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Behavioral Research to Improve MAT: Behavioral and Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R61/R33 Clinical Trial Optional) Apply for RFA AT 19 006 Funding Number: RFA AT 19 006 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) Apply for PA 19 127 Funding Number: PA 19 127 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed) Apply for PA 19 124 Funding Number: PA 19 124 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 19 126 Funding Number: PA 19 126 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Required) Apply for PA 19 129 Funding Number: PA 19 129 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) Apply for PAR 19 135 Funding Number: PAR 19 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) Apply for PAR 19 163 Funding Number: PAR 19 163 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| HIV/AIDS Clinical Trials Networks Laboratory Centers (UM1 Clinical Trial Required) Apply for RFA AI 19 001 Funding Number: RFA AI 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV Prevention Clinical Trials Network Leadership and Operations Center (UM1 Clinical Trial Required) Apply for RFA AI 19 005 Funding Number: RFA AI 19 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV/AIDS Clinical Trials Networks Statistical and Data Management Centers (SDMC) (UM1 Clinical Trial Required) Apply for RFA AI 19 002 Funding Number: RFA AI 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (R01 Clinical Trial Optional) Apply for RFA AI 19 022 Funding Number: RFA AI 19 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $350,000 |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (U01 Clinical Trial Optional) Apply for RFA AI 19 023 Funding Number: RFA AI 19 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
| BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 135 Funding Number: RFA MH 20 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Secondary Analysis and Archiving of BRAIN Initiative Data (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 120 Funding Number: RFA MH 20 120 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Brain Initiative: Research to Develop and Validate Advanced Human Cell-Based Assays To Model Brain Structure and Function (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 140 Funding Number: RFA MH 20 140 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| "Clinical Trials" on a Chip: Tissue Chips to Inform Clinical Trial Design and Implementation in Precision Medicine (UG3/UH3 - Clinical Trial Not Allowed) Apply for RFA TR 19 014 Funding Number: RFA TR 19 014 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trial Not Allowed) Apply for RFA EB 19 001 Funding Number: RFA EB 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
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