Opportunity Information: Apply for RFA AA 18 008
This funding opportunity is a limited-competition cooperative agreement (U01) from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the NIH within the Department of Health and Human Services. Its focus is the interaction between HIV infection and alcohol abuse and how that combination contributes to central nervous system (CNS) morbidity over time. The core scientific goal is to evaluate the cumulative and progressive effects of having HIV, alcohol abuse, or both conditions together on brain structure as well as cognitive and behavioral functioning. Because it is labeled "Clinical Trial Not Allowed," the supported work is intended to be observational and mechanistic in nature (for example, longitudinal tracking, imaging, neuropsychological assessment, and related analyses), rather than testing an intervention in a clinical trial format.
A key feature of the announcement is that it supports a competing renewal of an existing U01 project rather than launching a brand-new multi-site effort. The project being renewed has already recruited and followed a large cohort longitudinally, including groups with HIV infection alone, alcohol abuse alone, and the comorbid condition. The opportunity is built around leveraging that established cohort and the long-term data already collected, which is especially valuable now that many people with HIV are living longer due to effective antiretroviral therapy. With aging, longer duration of infection, and prolonged exposure to treatment, the cohort becomes particularly useful for answering newer questions that have become increasingly important in the HIV/AIDS research community.
The announcement highlights several priority scientific questions that the renewed project is expected to address. One is the impact of hepatitis C virus (HCV) coinfection, which is common in some populations affected by HIV and substance use and may add its own neurological and systemic burdens. Another is the role of peripheral neuropathy and how it may contribute to frailty, a growing concern as the HIV-positive population ages and experiences complex interactions among neurological impairment, mobility issues, and overall health decline. The opportunity also calls attention to the possibility of neurotoxic effects from antiretroviral medications, recognizing that long-term therapy, while life-saving, may carry risks that need careful measurement and interpretation, particularly in the brain and nervous system. Finally, it emphasizes the interactive effects of advancing age on sensory and motor functioning, pointing to a broader aim of understanding how HIV, alcohol exposure, and aging together shape trajectories of neurological function and day-to-day performance.
From an administrative and funding standpoint, this is a discretionary NIH opportunity using a cooperative agreement mechanism, meaning the funded project would be carried out with substantial NIH involvement compared with a standard research grant. The funding opportunity number is RFA-AA-18-008, and it is associated with CFDA 93.273 (alcohol research programs). The eligible applicant organization type listed is public and state-controlled institutions of higher education, reflecting the limited competition and likely expectation that the applicant is an established academic team already positioned to conduct the continuation work. The opportunity anticipated a single award (expected awards: 1), with an award ceiling of $800,000. The original posting date was December 13, 2017, and the original closing date was February 22, 2018.
In practical terms, the opportunity is about extending and deepening an ongoing longitudinal investigation, using an already-characterized cohort to clarify how HIV and alcohol abuse together affect the brain and behavior across time, and to refine understanding of emerging modifiers such as HCV coinfection, neuropathy-related frailty, potential medication-related neurotoxicity, and aging-related changes in sensory and motor systems. The overall intent is to produce evidence that is difficult to obtain without long-term follow-up and that can help the field better predict, monitor, and ultimately mitigate neurological complications in people living with HIV, particularly when alcohol abuse is also present.Apply for RFA AA 18 008
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Interaction of HIV Infection and Alcohol Abuse on Central Nervous System Morbidity Limited Competition (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on Dec 13, 2017.
- Applicants must submit their applications by Feb 22, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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