Opportunity Information: Apply for RFA AA 18 008
This funding opportunity is a limited-competition cooperative agreement (U01) from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the NIH within the Department of Health and Human Services. Its focus is the interaction between HIV infection and alcohol abuse and how that combination contributes to central nervous system (CNS) morbidity over time. The core scientific goal is to evaluate the cumulative and progressive effects of having HIV, alcohol abuse, or both conditions together on brain structure as well as cognitive and behavioral functioning. Because it is labeled "Clinical Trial Not Allowed," the supported work is intended to be observational and mechanistic in nature (for example, longitudinal tracking, imaging, neuropsychological assessment, and related analyses), rather than testing an intervention in a clinical trial format.
A key feature of the announcement is that it supports a competing renewal of an existing U01 project rather than launching a brand-new multi-site effort. The project being renewed has already recruited and followed a large cohort longitudinally, including groups with HIV infection alone, alcohol abuse alone, and the comorbid condition. The opportunity is built around leveraging that established cohort and the long-term data already collected, which is especially valuable now that many people with HIV are living longer due to effective antiretroviral therapy. With aging, longer duration of infection, and prolonged exposure to treatment, the cohort becomes particularly useful for answering newer questions that have become increasingly important in the HIV/AIDS research community.
The announcement highlights several priority scientific questions that the renewed project is expected to address. One is the impact of hepatitis C virus (HCV) coinfection, which is common in some populations affected by HIV and substance use and may add its own neurological and systemic burdens. Another is the role of peripheral neuropathy and how it may contribute to frailty, a growing concern as the HIV-positive population ages and experiences complex interactions among neurological impairment, mobility issues, and overall health decline. The opportunity also calls attention to the possibility of neurotoxic effects from antiretroviral medications, recognizing that long-term therapy, while life-saving, may carry risks that need careful measurement and interpretation, particularly in the brain and nervous system. Finally, it emphasizes the interactive effects of advancing age on sensory and motor functioning, pointing to a broader aim of understanding how HIV, alcohol exposure, and aging together shape trajectories of neurological function and day-to-day performance.
From an administrative and funding standpoint, this is a discretionary NIH opportunity using a cooperative agreement mechanism, meaning the funded project would be carried out with substantial NIH involvement compared with a standard research grant. The funding opportunity number is RFA-AA-18-008, and it is associated with CFDA 93.273 (alcohol research programs). The eligible applicant organization type listed is public and state-controlled institutions of higher education, reflecting the limited competition and likely expectation that the applicant is an established academic team already positioned to conduct the continuation work. The opportunity anticipated a single award (expected awards: 1), with an award ceiling of $800,000. The original posting date was December 13, 2017, and the original closing date was February 22, 2018.
In practical terms, the opportunity is about extending and deepening an ongoing longitudinal investigation, using an already-characterized cohort to clarify how HIV and alcohol abuse together affect the brain and behavior across time, and to refine understanding of emerging modifiers such as HCV coinfection, neuropathy-related frailty, potential medication-related neurotoxicity, and aging-related changes in sensory and motor systems. The overall intent is to produce evidence that is difficult to obtain without long-term follow-up and that can help the field better predict, monitor, and ultimately mitigate neurological complications in people living with HIV, particularly when alcohol abuse is also present.Apply for RFA AA 18 008
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Interaction of HIV Infection and Alcohol Abuse on Central Nervous System Morbidity Limited Competition (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on Dec 13, 2017.
- Applicants must submit their applications by Feb 22, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQs)
What is the main purpose of this funding opportunity?
This opportunity supports a longitudinal research effort focused on how HIV infection and alcohol abuse interact over time to contribute to central nervous system (CNS) morbidity. The core goal is to evaluate the cumulative and progressive effects of HIV alone, alcohol abuse alone, or the combination of both on brain structure and on cognitive and behavioral functioning.
Which agency is offering the award?
The award is offered by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), which is part of the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services.
What is the funding mechanism and what does it imply?
The mechanism is a limited-competition cooperative agreement (U01). A cooperative agreement generally involves substantial NIH involvement in the funded project compared with a standard research grant, reflecting a more active partnership in scientific and/or programmatic aspects.
Is this opportunity open competition or limited competition?
It is explicitly described as a limited-competition opportunity. It is designed to support a competing renewal of an existing U01 project rather than launching a brand-new effort.
Is this opportunity intended for new projects or renewals of an existing project?
It is intended to support a competing renewal of an existing U01 project that has already recruited and followed a large longitudinal cohort.
What makes the existing cohort especially valuable for this renewal?
The renewed project is expected to leverage an already-characterized cohort and long-term data that have been collected over time. This is particularly valuable because many people with HIV are living longer due to effective antiretroviral therapy, making it possible to study aging, longer infection duration, and prolonged treatment exposure in relation to neurological outcomes.
What types of participant groups are included in the cohort described?
The cohort includes groups with HIV infection alone, alcohol abuse alone, and the comorbid condition (both HIV infection and alcohol abuse), enabling comparisons across these conditions over time.
Does the funding opportunity allow clinical trials?
No. It is labeled "Clinical Trial Not Allowed," indicating the supported work is intended to be observational and mechanistic rather than testing an intervention through a clinical trial format.
What kinds of research activities fit the "Clinical Trial Not Allowed" scope described here?
The announcement describes observational and mechanistic activities such as longitudinal tracking, imaging, neuropsychological assessment, and related analyses. The emphasis is on measuring and interpreting changes over time rather than intervening with a trial-based treatment or behavioral program.
What are the primary scientific outcomes the project is expected to study?
The primary outcomes highlighted are changes in brain structure and changes in cognitive and behavioral functioning, assessed in relation to HIV, alcohol abuse, and their combined effects over time.
Why is CNS morbidity a central focus of this announcement?
The opportunity is centered on understanding how HIV infection and alcohol abuse, alone and together, contribute to neurological complications over time, including impacts on the brain and on cognitive and behavioral performance.
What priority scientific questions are specifically highlighted for the renewed project?
The announcement highlights several priority questions: the impact of hepatitis C virus (HCV) coinfection; the role of peripheral neuropathy and how it may contribute to frailty; potential neurotoxic effects of antiretroviral medications; and the interactive effects of advancing age on sensory and motor functioning.
How does hepatitis C virus (HCV) coinfection fit into the research priorities?
HCV coinfection is highlighted because it is common in some populations affected by HIV and substance use and may add neurological and systemic burdens. The renewed project is expected to address how HCV coinfection may modify CNS morbidity or related trajectories.
Why does the announcement emphasize peripheral neuropathy and frailty?
Peripheral neuropathy is called out because it may contribute to frailty, which is a growing concern as the HIV-positive population ages. The opportunity frames this as part of a complex interaction among neurological impairment, mobility issues, and overall health decline.
What does the opportunity say about antiretroviral medications and the nervous system?
It flags the possibility of neurotoxic effects from antiretroviral medications, recognizing that long-term therapy can be life-saving while still carrying potential risks. The announcement emphasizes careful measurement and interpretation of potential treatment-related effects, particularly in the brain and nervous system.
How is aging incorporated into the scientific goals?
Aging is emphasized as a key modifier because people with HIV are living longer. The opportunity specifically notes the interactive effects of advancing age on sensory and motor functioning and the broader goal of understanding how HIV, alcohol exposure, and aging together shape neurological trajectories and day-to-day performance.
What is the funding opportunity number?
The funding opportunity number is RFA-AA-18-008.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.273 (alcohol research programs).
How many awards were anticipated?
The announcement anticipated a single award (expected awards: 1).
What is the award ceiling for this opportunity?
The award ceiling listed is $800,000.
Who is eligible to apply based on the applicant organization type listed?
The eligible applicant organization type listed is public and state-controlled institutions of higher education, reflecting the limited-competition nature and the expectation of an established academic team positioned to continue the ongoing work.
When was the opportunity originally posted and when did it close?
The original posting date was December 13, 2017, and the original closing date was February 22, 2018.
What is the overall intent of the renewed project from a practical standpoint?
The intent is to extend and deepen an ongoing longitudinal investigation by leveraging an established cohort and long-term follow-up data to clarify how HIV and alcohol abuse together affect the brain and behavior across time, and to refine understanding of emerging modifiers such as HCV coinfection, neuropathy-related frailty, potential medication-related neurotoxicity, and aging-related sensory and motor changes.
Why does the announcement emphasize long-term follow-up?
The opportunity underscores that the evidence needed to understand cumulative and progressive CNS effects, and to evaluate newer modifiers that become more relevant with aging and prolonged treatment exposure, is difficult to obtain without long-term longitudinal follow-up.
What kinds of broader impacts does the announcement suggest this research could support?
The announcement suggests the work can help the field better predict, monitor, and ultimately mitigate neurological complications in people living with HIV, particularly when alcohol abuse is also present, by improving understanding of trajectories and modifiers of CNS morbidity.
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